You Already Make GLP-1. The Question Is Whether You're Making Enough.
GLP-1 is everywhere right now. It's in the news, it's on social media, and it's at the center of every conversation about weight management. But GLP-1 isn't new, and it isn't synthetic. It's a hormone your body has been producing your entire life.
GLP-1 Up is a daily plant-based supplement by Ora Organic containing four patented ingredients: Reducose (mulberry leaf extract), Morosil (blood orange extract), Eriomin (citrus flavonoid complex), and Feiolix (feijoa fruit powder). It is designed to support the body's natural GLP-1 production, promote satiety, and help maintain healthy blood sugar levels. Third-party tested under the 5 Nation Standard at ISO-accredited laboratories.
The real opportunity isn't finding a way to override your biology. It's giving your body what it needs to do its job better.
What GLP-1 Actually Does
GLP-1 stands for Glucagon-Like Peptide-1. It's a hormone produced in your gut after you eat, and it plays three critical roles in how your body processes a meal (Muller et al., Molecular Metabolism, 2019):
- It tells your brain you're full. GLP-1 signals satiety directly to your brain. That feeling of being genuinely satisfied after a meal, not stuffed, not still reaching for snacks, that's GLP-1 doing its job.
- It slows digestion. GLP-1 reduces the speed at which food leaves your stomach. You stay satisfied longer, and your bloodstream doesn't get hit with a sudden rush of sugar all at once.
- It sharpens your insulin response. GLP-1 helps your pancreas release the right amount of insulin at the right time. This keeps blood sugar stable and helps your body use energy from food efficiently.
One hormone. Three functions. All of them matter for metabolic health.
Two Approaches to GLP-1: Drugs vs. Nutrients
GLP-1's importance has made it a major focus in both pharmaceutical development and nutrition science. The two approaches work very differently.
What Are GLP-1 Drugs?
GLP-1 receptor agonists (you may know them as Ozempic or Wegovy) are synthetic compounds designed to mimic your natural GLP-1. They bind to the same receptors but are engineered to be far more potent and longer-lasting than anything your body produces on its own.
These drugs can produce significant results. They can also come with a high price tag, regular injections, and side effects including nausea and digestive discomfort (FDA prescribing information, semaglutide). Research has also raised concerns about the loss of lean muscle mass alongside fat, which can affect long-term strength and metabolic function (Ida et al., Diabetes & Metabolism, 2024).
What Is the Nutritional Approach?
Instead of introducing a synthetic mimic, you can provide your body with specific plant-based compounds that clinical research shows support your natural GLP-1 production and function. This is the approach we took with GLP-1 Up.
It's not a replacement for prescription medication. It's a different category entirely: targeted nutritional support for the biological system you already have.
GLP-1 Up is a dietary supplement. It is not intended to diagnose, treat, cure, or prevent any disease. Consult your healthcare provider before making changes to your health regimen.
What Are the Ingredients in GLP-1 Up?
Four patented, clinically studied ingredients. Each one chosen for a specific role in metabolic support.
Eriomin Citrus Flavonoid Complex.
A standardized blend of citrus flavonoids derived from lemons, composed primarily of eriocitrin (70%), with hesperidin and naringin. In a 12-week, double-blind, randomized controlled trial in prediabetic patients, 200mg/day of Eriomin increased GLP-1 blood levels by 22% and reduced fasting blood glucose by 6%, both statistically significant versus placebo (p<0.05). The same research group also demonstrated improvements in insulin resistance (7% reduction), glucose intolerance (7% reduction), and reversal of prediabetes status in 24% of participants. (Ramos et al., Food Science & Nutrition, 2023; Cesar et al., Journal of Medicinal Food, 2022)
Reducose Mulberry Leaf Extract.
A proprietary water extract of white mulberry leaves standardized to 5% DNJ (1-deoxynojirimycin), which works as a natural alpha-glucosidase inhibitor. In a randomized, double-blind, placebo-controlled crossover trial at Oxford Brookes University, 250mg of Reducose reduced peak postprandial blood glucose by 42% and postprandial insulin by 41% versus placebo. A subsequent trial using a complete meal (rather than sugar alone) confirmed 30-33% reductions in blood glucose and 31-38% reductions in insulin across three dose levels. (Thondre et al., PLOS ONE, 2021; Lown et al., Nutrients, 2024)
Morosil Blood Orange Extract.
A standardized extract from Sicilian Moro blood oranges, rich in anthocyanins (particularly cyanidin 3-glucoside). In a 6-month, randomized, double-blind, placebo-controlled trial of 98 overweight but otherwise healthy adults, 400mg/day of Morosil produced significantly greater reductions in body mass (4.2% vs. 2.2%, p=0.015), waist circumference (3.9cm vs. 1.7cm, p=0.017), hip circumference (3.4cm vs. 2.0cm, p=0.049), and both visceral and subcutaneous fat mass compared to placebo. Lean muscle mass was maintained. All safety markers of liver toxicity remained within normal range. (Briskey et al., Nutrients, 2022)
Feiolix Feijoa Fruit Powder.
A freeze-dried powder derived from New Zealand-grown feijoa fruit (Acca sellowiana, also known as pineapple guava). Feijoa is naturally rich in polyphenols, dietary fiber, vitamin C, and abscisic acid, a compound that supports insulin secretion from the pancreas and promotes stronger insulin signaling and glucose absorption by muscle cells.
The soluble fiber content supports satiety by slowing gastric emptying, and the polyphenol profile contributes to modulation of gut microbiota and reduction of oxidative stress. In the FERDINAND randomized controlled trial, daily feijoa fruit powder supplementation enhanced improvements in fasting plasma glucose and blood pressure when combined with a dietary intervention in adults with overweight and prediabetes (FERDINAND study, medRxiv, 2026; Phan et al., Foods, 2019).
Why These Four Together
"Most metabolic support products contain one or two ingredients at modest doses and call it a formula. GLP-1 Up was built differently. Each of the four ingredients addresses a different part of the metabolic pathway: Eriomin works on GLP-1 production and insulin sensitivity. Reducose moderates the glucose load from your meal. Morosil supports healthy body composition over time. And Feiolix extends satiety through fiber and polyphenol activity. They're not redundant. They're complementary. That's what formulation should look like."
- Gerry Wong, Chief Product Officer - Ora.
What to Expect
Supporting your body's GLP-1 system is not a quick fix. It builds over time with consistent use.
- First few weeks: Many users notice more stable energy after meals and a reduction in sugar cravings. You may feel less driven to snack between meals.
- After one month: This is when the effects typically become more noticeable. Fuller after meals. Less urge to graze. More consistent energy across the day.
- After three months: With consistent daily use, the clinical data behind the ingredients suggests meaningful metabolic support. The Eriomin research showed the 22% GLP-1 increase and 6% blood glucose reduction at the 12-week mark (Ramos et al., 2023). The Morosil body composition data reached statistical significance at both 12 weeks and 6 months (Briskey et al., 2022). Consistency matters.
Other Ways to Support Your GLP-1 System
GLP-1 Up works best as part of a healthy routine. Research shows several dietary and lifestyle factors directly influence your body's GLP-1 production (Bodnaruc et al., Physiology & Behavior, 2016):
Fiber and protein.
Foods rich in soluble fiber (oats, beans, apples) and plant protein (lentils, tofu, quinoa) stimulate your gut to release more GLP-1. Our So Lean & So Clean organic plant protein delivers 23g of complete protein per serving with digestive enzymes for absorption support.
Healthy fats.
Avocados, nuts, olive oil. Fat is essential for satiety and plays a direct role in GLP-1 release.
Regular movement.
Exercise improves your body's sensitivity to its own hormones, including GLP-1. This is part of building metabolic flexibility: the ability to efficiently switch between fuel sources based on what your body needs.
For more: A science-backed approach to boosting GLP-1 naturally. Also see: 4 science-backed supplements to complement your GLP-1 journey and understanding blood sugar spikes and crashes.
Quality You Can Verify
GLP-1 Up is third-party tested under the 5 Nation Standard at ISO-accredited laboratories. Every batch is tested for heavy metals, microbiology, and active ingredient potency before release, benchmarked against USP and EU standards. We publish batch-specific Certificates of Analysis on our website.
Performance Enhancing Plants™ means clinically studied ingredients at effective doses, verified by independent testing. No fillers. No shortcuts.
Pricing
GLP-1 Up is available as a one-time purchase or through subscribe and save (20% off every order, free shipping on subscriptions over $100, pause or cancel anytime). GLP-1 Up is also HSA/FSA eligible through our TrueMed partnership.
For comprehensive metabolic support, the Metabolic Reset bundle pairs GLP-1 Up with complementary Ora products.
Frequently Asked Questions
Is GLP-1 Up safe? GLP-1 Up is formulated with patented, clinically studied plant extracts and is third-party tested at ISO-accredited laboratories under the 5 Nation Standard. As with any supplement, consult your healthcare provider before use, especially if you are pregnant, nursing, or taking medications.
How long does it take to work? Results vary. Some users notice more stable energy and reduced cravings within the first few weeks. The clinical data behind the ingredients suggests more significant metabolic benefits build over one to three months of consistent daily use. The Eriomin study demonstrating a 22% GLP-1 increase was conducted over 12 weeks.
Can I take GLP-1 Up with other supplements? GLP-1 Up is designed to complement a healthy routine and pairs well with a quality protein supplement like So Lean & So Clean. If you take prescription medications, consult your healthcare provider to confirm compatibility.
Is GLP-1 Up third-party tested? Yes. Every batch is tested under the 5 Nation Standard at ISO-accredited laboratories. Testing limits and pass/fail results are published as batch-specific Certificates of Analysis on our website.
How is GLP-1 Up different from GLP-1 drugs? GLP-1 drugs like Ozempic and Wegovy are prescription medications that introduce a synthetic compound to mimic your GLP-1 hormone at much higher potency. GLP-1 Up is a dietary supplement that provides plant-based nutrients studied to support your body's own natural GLP-1 production and function. They are different categories with different mechanisms, different regulatory classifications, and different use cases. GLP-1 Up is not a substitute for prescription medication.
Can I use HSA or FSA funds? Yes. GLP-1 Up is eligible for purchase with HSA/FSA funds through our TrueMed partnership.
Sources Referenced
- Muller TD, et al. "Glucagon-like peptide 1 (GLP-1)." Molecular Metabolism. 2019. https://pubmed.ncbi.nlm.nih.gov/30905604/
- Ramos FMM, et al. "Lemon flavonoids nutraceutical (Eriomin) attenuates prediabetes intestinal dysbiosis: A double-blind randomized controlled trial." Food Science & Nutrition. 2023. https://pubmed.ncbi.nlm.nih.gov/37970408/
- Cesar TB, et al. "Nutraceutical Eriocitrin (Eriomin) Reduces Hyperglycemia by Increasing Glucagon-Like Peptide 1 and Downregulates Systemic Inflammation." Journal of Medicinal Food. 2022. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9700344/
- Thondre PS, et al. "Mulberry leaf extract improves glycaemic response and insulaemic response to sucrose in healthy subjects." PLOS ONE. 2021. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8047566/
- Lown M, et al. "Understanding the Impact of Different Doses of Reducose Mulberry Leaf Extract on Blood Glucose and Insulin Responses after Eating a Complex Meal." Nutrients. 2024. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11174565/
- Briskey D, et al. "Effectiveness of Moro Blood Orange Citrus sinensis Osbeck Standardized Extract on Weight Loss in Overweight but Otherwise Healthy Men and Women." Nutrients. 2022. https://pubmed.ncbi.nlm.nih.gov/35276783/
- FERDINAND Study Group. "Evaluating whole fruit feijoa powder for type 2 diabetes risk prevention: the FERDINAND RCT." medRxiv. 2026. https://www.medrxiv.org/content/10.1101/2025.06.18.25329000v2 7b. Phan ADT, et al. "Nutritional Characteristics and Antimicrobial Activity of Australian Grown Feijoa (Acca sellowiana)." Foods. 2019. https://www.mdpi.com/2304-8158/8/9/376
- Bodnaruc AM, et al. "Nutritional modulation of endogenous glucagon-like peptide-1 secretion." Physiology & Behavior. 2016. https://pubmed.ncbi.nlm.nih.gov/30166637/
- FDA. Prescribing information, semaglutide. https://www.accessdata.fda.gov/drugsatfda_docs/label/2023/215256s007lbl.pdf
- Ida S, et al. "Effect of GLP-1 receptor agonists on muscle mass." Diabetes & Metabolism. 2024. https://pubmed.ncbi.nlm.nih.gov/38583573/